>PACK LIGHT / CARRY-ON ONLY
Pack light Pack light Pack light.
Reasons for this:  You'll walk more with your luggage than you ever expect - even on a tour.
Also, carry-on allows flight flexibility - you can standby for the earlier flight that cuts short that long layover (not allowed with checked bags).
Bonus:  A liberating vacation from our daily burden of possessions - distill to essentials!   
So!  Lay out everything you think you need and take away a third.  Strive for carry-on only.
Buy the right suitcase (see
Equipment).
One suitcase and one daypack per person.


>SHOES

Start wardrobe planning with shoes:
(I can't say enough about footwear importance)
2 pairs plus flip flops or crushable sandals:
First pair - good quality waterproof walking/hiking.
Second pair - back-up that can be used to give feet a rest from first pair and when first pair get wet or muddy.  Still need to be able to walk around London all day in this pair.  There are some good packable options out there.
Lastly, flip flops or sandals for pool-side, dirty showers, beach wear, around hotel.
Water shoes or Teva types good option here too.
NEVER take new shoes on a trip.  If you buy something - do it at least a couple weeks in advance and wear them a lot before departure.


>CLOTHING

Make sure all tops go with all bottoms for maximum combinations out of minimal pieces.
Look for reversible and convertible pieces - ie. zip-off pants and reversible knit cold weather layer in two colors.
Choose a good quality rain parka with hood and drawstrings for outermost layer.
No jeans - they pack thick and don't dry readily.  
Plan on washing - especially socks and undies - along the way.
  Or another good strategy - bring items that are on a 'one-way trip' and just leave them behind.  Often someone in your host country will be glad to get them, and then room for souvenir purchases magically appears!  

>LAYERS

Layers are the key for dealing with weather variations, rather than carrying a big thick coat (unless taking an Antarctic or more extreme trip).
Start with warm weather layer and work outward:  t-shirt or tank top first, then short-sleeved shirt and/or long-sleeved shirt, then warm layer (fleece, hoodie, reversible sweater, etc.), then rain jacket.  Don't start with a turtleneck (again, unless in a more extreme trip) because it's hard to take off later in day when it warms up.
*See
notes in PACKING LIST below for more tips...
(copy / paste / print):

cash - small bills best
credit cards - two types, in case one doesn't 'go thru'
travelers checks - use as emergency funds and to convert
phone calling card
drivers license
airline tickets
passport / visa
immunization records - if required, check carefully
photocopies of above - trimmed and kept in separate place
addresses / phones / email / emergency contacts both home and abroad -
  check
US Dept. of State International Travel).
moneybelt - more in
Cautions
luggage tags / TSA locks
pens, pencil / notepad
guidebook / maps
language book
itinerary
novel / journal
wet wipes - single pack

airplane food
toiletry case - thin, waterproof
shampoo / conditioner
soap - liquid works well
  (all liquid toiletries in good quality small travel bottles 
  and within ziplocks)
toothpaste / toothbrush / floss
brush/comb
vaseline
first aid kit - small
meds - combo of: antibiotics / antibacterial cream / cortisone / Pepto / Imodium / pain-reliever / Ex-Lax / vitamins / RX
Kleenex - couple travel packs
nail clipper / file
shaving needs
for women:  feminine items / pocket mirror / lotion /
  hair clips or bands 
make up - minimal
jewelry - minimal and not irreplaceable
sewing kit
sunscreen
insect repellent (no aerosols, look for stick type)
  see
Cautions
eye needs:  contacts, solution / reading glasses /  
  sunglasses / case
plastic fork / spoon / can opener
baggies - few large, few small, myriad uses
bungee or rubber bands
thin nylon cord for clothesline
camera / battery(ies)
extra storage / film
charger - outlet / car
voltage/current adaptor/convertor
binoculars - see
Equipment
pouch/case
safety chain
raincover
bird book
lens paper
scope / tripod
flashlight - small, or penlight

alarm clock - travel style
watch - cheap, w/ new battery or windup type
extra batteries
compass - small, zipper clip-on type
raincoat - parka style w/ hood
rain pants - thin nylon
hat - crushable
swimsuit - men can use zip-off pants
  (tankini type works well for women - top can be worn
  alone)
scarf/bandanna - many uses
shoes - 2-3 pairs - see
PACKING TIPS above
pants - 1 pair chinos (for airplane), 2 pairs cargo or zip-offs
  shorts - optional / use zip-offs
skirts - 1-2, depending on preference, good for airplane
t-shirts - 2-3
shirts - 2-3 long sleeve, 2-3 short sleeve
sweater/warm layer - choose carefully - make sure thin  
  and packable
socks / undies - 4-6 pairs
bra - 2 
belt

nylon or net bag - flattens to almost nothing, for  
  souvenirs, dirty clothes, etc.
>If traveling w/ kids (limit to what child can carry in own daypack):
small toys / games / cards
Gameboy type w/ charger or batteries
books
snacks
small sketchpad / colored pencils / little sharpener
Beanie baby friend (not irreplaceable)
small ball or nylon frisbee
>Following optional, depending on trip and preferences (not all carry-on items):
tent
sleeping bags / pads
ground cloth
snorkel gear
harmonica
laptop
small hard drive device (for digital pic storage, etc.)
MP3 birdsong system
insect net - head, etc.
laser pointer

walkie talkies
GPS
cell phone / charger
water bottle - not often needed, bottled water widely
  available
gloves / stocking hat - depending on trip
towel - optional, thin packable hand-towel size
bowl / cup - optional, depending on type of trip
vest - birder's type, w/ pockets
Daypack, Peruvian style
Flamingos, Rift Valley, Kenya
Raingear in good use, Amazonia